(A) Disulfide bonds in a 20-residue peptide can be formed only if the cysteines are adjacent to each other
(B) The amino acid isoleucine has only one chiral centre
(C) Both bases and sugar contribute to chirality of nucleic acids
(D) The pI of aspartic acid is less than that of glutamic acid
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Q.2 What is the effect of sudden increase in the levels of ATP and citrate on an erythrocyte undergoing glycolysis? ?
(A) It inhibits glycolysis
(B) It stimulates glycolysis
(C) The rate of glycolysis remains unaltered
(D) The rate of glycolysis increases gradually
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Q.3 Indicate the INCORRECT statement from the following ?
(A) Allosteric enzymes function through reversible noncovalent binding of allosteric modulators or effectors
(B) Monoclonal antibodies that catalyze hydrolysis of esters or carbonates can be produced
(C) Enzymes are not inhibited irreversibly by heavy metals such as Hg2+, Ag+.
(D) Acid phosphatases hydrolyze biological phosphate esters at ~ pH 5.0.
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Q.4 The ɸ and Ψ values of a β-strand composed of all D-amino acids will mainly occupy which quadrant in the Ramachandran plot? ?
(A) Upper left
(B) Upper right
(C) Lower left
(D) Lower right
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Q.5 In a signalling event, binding of an extracellular ligand activates G-protein coupled receptor (GPCR) that eventually activates phospholipase C-β. Which one of the following statements truly reflects the function of phospholipase C-β ? ?
(A) Phospholipase C-β converts PI (3,4,5)P3 to PI (4,5)P2
(B) Phospholipase C-β converts PI (4)P to PI (4,5)P2
(C) Phospholipase C-β converts PI (4,5)P2 to diacylglycerol and IP3
(D) Phospholipase C-β converts PI (5)P to PI (4,5)P2
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Q.6 Which one of the following statements about chromatin is NOT true? ?
(A) DNA winds approximately 1.65 times around the nucleosomes
(B) H2A-H2B bind to both the entry and exit ends of DNA in nucleosomes
(C) Covalent modification of histones influence chromatin compaction
(D) Non-histone proteins are part of mitotic chromosomes
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Q.7 Select a cellular body which is NOT a part of the nuclear bodies: ?
(A) P-bodies
(B) Nucleolus
(C) Cajal bodies
(D) Interchromatin granule clusters
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Q.8 During eukaryotic cell division, metaphase to anaphase transition is regulated by degradation of ?
(A) Cyclin B1
(B) CDK1
(C) Aurora A kinase
(D) Polo-like kinase
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Q.9 One of the mechanisms used by bacteria for adaptation to changed environment is altering transcription of their genes. In this regard, which one of the following responses is NOT found in bacteria? ?
(A) A gene with two different promoters for expression in different conditions
(B) Use of different sigma factors for transcri- ption of genes
(C) Expression of alternate α, β and βʹ subunits
(D) Expression of anti-sigma factors
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Q.10 Which one of the following λ proteins acts both as an activator and repressor of transcription? ?
(A) cI protein
(B) N protein
(C) cII protein
(D) Q protein
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Q.11 A highly specific inhibitor that targets the phosphorylation activity of TFIIH is added to an in vitro transcription reaction. Which one of the following steps is most likely to be affected? ?
(A) Binding of RNA polymerase to promoter sequence
(B) Promoter clearance
(C) Recruitment of TFIID
(D) Open promoter complex formation
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Q.12 During eukaryotic protein synthesis, stress conditions result in activation of specific kinases leading to phosphorylation of a key translation initiation factor that inhibits protein synthesis from a large number of cellular mRNA. Which one of the following factors is the target of the kinase? ?
(A) eIF4E
(B) eIF4G
(C) eIF2α
(D) Gcn4
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Q.13 Proteins with cytoplasmic domains having tyrosine kinase activity do NOT act as receptors for ?
(A) Epidermal growth factor (EGF)
(B) Platelet-derived growth factor (PDGF)
(C) Insulin
(D) Transferrin
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